INCREASING EFFICACY OF RECANALIZATION OF INFARCTION-ASSOCIATED CORONARY ARTERY BY MEANS OF PHARMACOLOGICAL AGENT IMITATING PRE- AND POSTCONDITIONING PHENOMENON (REVIEW OF LITERATURE)

Maslov L.N., Khaliulin I.G., Vang H., Pey G.M.
Scientific Research Institute of Cardiology under the Siberian Branch of the RAMS,
Tomsk State Pedagogical University, Tomsk, Russia
Bristol University, Bristol, Great Britain
Liaonig Medical College, China

Analyzing the literature data shows that the formation of the necrosis focus in patients presenting with acute myocardial infarction (AMI) is mainly completed within 2-4 hours from the moment of the development of coronary thrombosis. A positive effect of thrombolytic therapy and coronary angioplasty observed at later terms is apparently associated with restoration of coronary perfusion in the periinfarction zone. The protecting effect of adenosine in acute myocardial infarction (AMI) does not probably depend upon the size of the infarction focus but is due to decreased incidence of the development of the no-reflow phenomenon. The protective effect on nicotinamide seen in patients with AMI is probably associated with improved coronary perfusion in the periinfarction zone. Opioids and cannabioids imitate the pre- and postconditioning phenomenon. Hence, these compounds after cl employed in comprehensive therapy of AMI.

KEY WORDS: heart, ischaemia, reperfusion, adenosine, nicorandyl, opioids, cannabioids.

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