Comparative pharmacoeconomic analysis of prostanoids for peripheral arterial occlusive

Avxentyeva M.V.^1,2, Chupin A.V.³

1) National Centre for Health Technology Assessment,
2) First Moscow State Medical University named after I.M. Sechenov,
3) Clinical Hospital N83 of Federal State Medico-Biological Agency, Moscow, Russia

Peripheral arteries occlusive disease (PAOD) is a prevalent illness that needs improved pharmacological management, especially for patients not eligible for surgical revascularization. Prostanoids (alprostadil or iloprost) were shown to be effective in PAOD and critical limb ischemia (CLI) but are rather costly. The results of our pharmacoeconomic study (cost estimation based on randomized control trial results) showed that iloprost does not increase cost of treatment when only direct medical costs are taken into account. If indirect costs are included into the analysis iloprost saves up to 27 thousand rubles per patient. Clinical efficacy is still high. Thus iloprost is a better alternative than alprostadil for CLI.

KEY WORDS: critical limb ischemia (CLI), iloprost, alprostadil, pharmacoeconomic analysis.

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