Administration of dalteparin in reconstructive vascular surgery

Pokrovsky A.V., Gontarenko V.N., Titova M.I.
Department of Vascular Surgery, State Federal Facility «A.V. Vishnevsky Institute of Surgery» under the Russian Federation Ministry of Public Health and Social Development,
Moscow, Russia

The article contains a review of the literature regarding the use of low-molecular-weight heparins (LMWHs) exemplified by dalteparin in the hitherto insufficiently explored area of their implementation, i. e., during the intraoperative period in patients suffering from atherothrombosis. Presented herein is analysis of alterations in the parameters of the plasmatic and thrombocytic links of haemostatis during intraoperative administration of various molecular-weight fractions of heparin. The obtained findings make it possible to conclude that LMWHs do offer certain advantages when used during surgical interventions in patients with atherosclerotic lesions of the arterial bed.

KEY WORDS: atherothrombosis, low-molecular-weight heparins, dalteparin, unfractionated heparin, vascular surgery.

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