Possibilities of pharmacokinetic modelling of venotonics illustrated by an example of flavonoids

Savelyeva M.I., Sychev D.A.

Russian Medical Academy of Continuing Professional Education under the RF Ministry of Public Health, Moscow, Russia

Studying the structure of flavonoids, as well as the processes of their absorption, metabolism, distribution and elimination is of interest from the point of view of the inter- and intra-specific variability of pharmacokinetic parameters obtained both in laboratories and clinical conditions. Pharmacological application of flavonoids appears to be limited due to peculiarities of the structure and metabolism, thus requiring search for ways to improve their absorption.

Discussed in the article are peculiarities of metabolism of flavonoids, methods of correcting the effect of variability of pharmacokinetic parameters on bioavailability and in the long run on realization of the clinical effect. The use of micronization is regarded as the most optimal and currently acceptable method of increasing bioavailability of flavonoids.

KEY WORDS: flavonoids, diosmin, hesperidin, pharmacokinetics, absorption, metabolism, pharmacodynamic effect.

P. 80

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