Genetic engineering technologies of stimulating angiogenesis as an innovation trend in angiology and vascular surgery

Gavrilenko A.V.^1,2, Voronov D.A.^1,2

1) Vascular Surgery Department, B.V. Petrovsky Russian Research Centre of Surgery under the Russian Academy of Medical Sciences,
2) Chair of Cardiovascular Surgery No1 named after B.V. Petrovsky, Institute of Professional Education of the First Moscow State Medical University named after I.M. Sechenov, Moscow, Russia

Presented herein is a review of the principles, fundamental concepts, and possibilities of genetic engineering technologies of stimulating angiogenesis for treatment of patients with lower limb chronic ischaemia. This is followed by a detailed discussion of the structure and results of Russian and foreign studies on this direction, also considering the causes of differences of their results. Outlined is a circle of clinical situations in relation to which these technologies may be regarded as most promising.

KEY WORDS: lower limb chronic ischaemia, angiogenesis, stimulation of angiogenesis, genetic engineering technologies, translational medicine, gene therapy, vascular endothelial growth factor, angiogenin.

P. 14

« Back