Journal «Angiology and Vascular Surgery» • 

2012 • VOLUME 18 • №1

Inflammation of the vascular wall and hyperhomocysteinemia in patients with atherosclerosis obliterans of lower limb arteries

Arzamastsev D.D.1, Karpenko A.A.2, Kostyuchenko G.I.1

1) Department of Roentgenographic Methods of Diagnosis and Treatment No2 Territorial Clinical Hospital, Barnaul, Russia
2) Scientific Research Institute for Circulatory Pathology named after Academician E.N. Meshalkin, under the RF Ministry of Public Health and Social Development, Novosibirsk, Russia

Presented herein are the findings of examination of 176 people. Of these, 128 were found to suffer lower limb atherosclerosis (LLA) and 48 were apparently healthy people constituting a control group. Amongst the 128 patients, 74 (58%) had atherosclerotic lesions of the iliac arteries, 54 (42%) subjects had lesions of the femoral and popliteal arteries. The average age of the patients amounted to 62.4±4.3 years. There were ten (8%) women and 118 (92%) men. The control group consisted of 42 (89%) men and six (11%) women. The mean age of the control group patients was 58.9±3.2 years. All underwent functional and laboratory examinations including angiography, duplex scanning and dopplerography of lower limb arteries, as well as determining blood serum markers of inflammation (hs-CRP and IL-6), as well as endothelial lesion markers (ET-1 and VWF). The comparative analysis revealed that patients with LLA had signs of chronic vascular inflammation accompanied in the majority of cases by hyperhomocysteinemia with endothelial dysfunction, as well as direct association between the degree of the vascular inflammatory reaction and severity of clinical manifestations of lower limb ischaemia.

KEY WORDS: atherosclerosis, inflammation, hyperhomocyste-inemia.

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