RANDOMIZED PLACEBO-CONTROLLED STUDIES OF ILOPROST IN TREATMENT OF LOWER LIMB CRITICAL ISCHAEMIA

Kharazov A.F.
Department of Clinical Angiology and Vascular Surgery Russian Medical Academy of Postgraduate Education,
Moscow, Russia

The article deals with the analysis of the treatment outcomes obtained in management of patients suffering from lower-limb critical ischaemia treated with iloprost, a stable analogue of the prostacyclin. The results of six randomized placebo-controlled trials and eleven trials of other drugs are described in this article. The meta-analysis of the iloprost studies confirmed the efficacy of the drug in decreasing the size of ulcers, pain relief, extremity amputation rate. Whereas the other examined drugs have not demonstrated such properties with rare exception.

KEY WORDS: peripheral artery disease, critical ischaemia, prostaglandins, Iloprost.

P. 27-33

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