SYMPTOM-FREE PHLEBOTHROMBOSIS AND HEREDITARY THROMBOPHILIA IN PATIENTS WITH A SKELETAL INJURY

Asamov R.E., Tulyakov R.P., Muminov Sh.M., Dadamyants N.G., Shukurov B.I., Valiev E.Yu.
Department of Vascular Surgery and Microsurgery Republican Scientific Centre for Emergency Medical Care,
Tashkent, Uzbekistan

The authors have studied the frequency of revealing phlebothrombosis of the system of the inferior vena cava (IVC) in the acute period of a mechanical injury by means of coloured duplex scanning (CDS). Formulated herein are both treatment policy and principles of prevention of thromboembolic complications in severe lesions of the locomotor system. Carried out was a screening sonographic examination of the IVC bed in a total of 137 injured people on days 3 and 7 after a skeletal wound. Of these, 24 patients who later on were diagnosed with phlebothrombosis signs underwent the molecular genetic testing of DNA by means of the polymerase chain reaction (PCR) in order to determine hereditary predisposition to thrombogenesis (genetically conditioned thrombophilia). It was found that the incidence rate of symptom-free thrombosis of the IVC bed in those presenting with fractures of pelvic bones and lower extremities amounted to 17.5%. As surgical prevention suggested herein is the authors' technique of IVC clipping.

KEY WORDS: venous thrombosis, inferior vena cava, pulmonary thromboembolism, injury, thrombophilia.

P. 73-76

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