Comprehensive treatment of a patient with Buerger's disease using genetically engineered complexes VEGF-165

Gavrilenko A.V.^1,2, Oleinik E.M.^2,3

1) Department of Vascular Surgery, Russian Research Centre of Surgery named after Academician B.V. Petrovsky,
2) First Moscow State Medical University named after I.M. Sechenov under the RF Ministry of Public Health,
3) Scientific Clinical Centre of the Open Joint-Stock Company "Russian Railways", Moscow, Russia

Buerger’s disease, also known as thromboangiitis obliterans, is a severe invalidating systemic vascular disease. To one of the modern methods, which is distinguished by its radically new principles of action, as well as holding much promise for further study and application in treatment of patients with lower limb chronic ischaemia induced by thromboangiitis obliterans belongs the use of genetically engineered complexes based on vascular endothelial growth factor VEGF-165 ("Neovasculgen").

"Neovasculgen" is a genetically engineered complex being a circular DNA (native plasmid on the CELO vector and Ad5), carrying the human VEGF-165 gene, encoding VEGF synthesis. Injection of this drug to the ischaemised tissues of lower extremities ensures long-term synthesis of vascular endothelial growth factor 165 leading to the development of an additional collateral vascular network and consequently to increased perfusion of tissues with oxygen and decreased degree of ischaemia.

Presented herein is a clinical case report of a successful therapeutic outcome achieved in a patient suffering for a long time from thromboangiitis obliterans (Buerger’s disease) and treated with genetically engineered complexes based on vascular endothelial growth factor ("Neovasculgen") used as a component of comprehensive conservative therapy.

KEY WORDS: Buerger’s disease, thromboangiitis obliterans, plasmid DNA, VEGF-165 gene, stimulation of angiogenesis, lower limb chronic ischaemia.

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