Diosmin-containing phlebotropic drugs in varicose eczema

Rodnyansky D.V.¹, Fokin A.A.²

1) Department of Vascular Surgery, Railway Clinical Hospital at the Chelyabinsk Station of the Open Joint-Stock Company "Russian Railways",
2) Department of Surgery of the Institute of Additional Professional Education, South Ural State Medical University of the RF Ministry of Public Health, Chelyabinsk, Russia

Objective. The purpose of the study was to examine the effect of diosmine-based phlebotropic drugs on dynamics of regress of varicose eczema in patients with chronic venous diseases, to compare their objective complaints and subjective symptoms before and after treatment, to determine the time of improvement.

Patients and methods. The study enrolled a total of 80 patients presenting with chronic venous diseases complicated by varicose eczema (CEAP class C4A). The patients of the Study Group received combined treatment: elastic compression of lower extremities, phlebotropic agents (diosmin 450 mg + hesperidin 50 mg, "Venarus" (manufactured by the Limited Liability Company "Obolenskoe", Russia)) and a dermatologist’s prescribed topical treatment. The patients of the Comparison Group received similar treatment with the exception of phlebotropic drugs, however taking penoxiphylline at a daily dose of 1200 mg.

Results. The obtained findings demonstrated a decrease in pain intensity, lowered exudation, achievement of complete remission and reduced area of eczema with statistically significant differences in the groups.

Conclusion. Modern phlebotropic drugs based on diosmin proved to be effective agents in comprehensive treatment of chronic diseases of lower-limb veins and varicose eczema.

KEY WORDS: chronic venous diseases, phlebotropic drugs, diosmin, varicose eczema, Venarus.

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