The place of novel oral anticoagulants in prevention and treat-ment of venous thromboembolism

Petrov V.I.¹, Shatalova O.V.², Maslakov A.S.², Shatalov A.A.²

1) Chair of Clinical Pharmacology and Intensive Therapy with courses of Clinical Pharmacology of the Faculty of Advanced Medical Training, Clinical Allergology of Faculty of Advanced Medical Training, Volgograd State Medical University under the Ministry of Public Health of the Russian Federation,
2) Departmental Clinical Hospital of the Volgograd-1 railway station of the Open Joint Stock Company "Russian Railways"», Surgical Department, Volgograd, Russia

The notion "venous thromboembolism" combines two processes: thrombosis of deep veins and pulmonary artery thromboembolism. The necessity in long-term adequate anticoagulant therapy as the basic treatment of patients with deep vain thrombosis does not give rise to doubts, it should be started prior to instrumental verification of the diagnosis. The past decade was marked by the appearance on the pharmaceutical market of a new oral anticoagulant: selective blocker of the Xa factor of blood coagulation system – rivaroxaban. According to the data of large-scale randomized clinical trials, the efficacy and safety of rivaroxaban are comparable to those of traditional conventional anticoagulant therapy (non-fractionated/low-molecular-weight heparin NFH/LMW+warfarin). Indisputable advantages of new agents are as follows: the lack of the necessity in laboratory monitoring, no interaction with foodstuff, minimal interaction with other drugs, minimal risk for the development of haemorrhage, and simplicity of dosing.

KEY WORDS: new oral anticoagulants, rivaroxaban (Xarelto), venous thromboembolism, deep vein thrombosis.

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