State of kinin regulation and endothelial function in patients with ischaemic stroke

Bekbosynov A.Zh.

Municipal Hospital No 1, Chair of Surgery, Pavlodar Branch of the State Medical University of the city of Semey Pavlodar, Kazakhstan

The study was aimed at assessing the degree of impairments of the kinin mechanisms by the level of antibodies to bradykinin in patients with ischaemic stroke in association with the indices of the vascular endothelium function.

We examined people belonging to four various categories, i.e. 30 apparently healthy people (the control group), 30 high-risk patients with degree I–II arterial hypertension, 56 patients with degree II–III arterial hypertension running very high risk for cardiovascular disease, and 35 patients undergoing in-hospital treatment for acute stage of ischaemic stroke. We determined the content of natural antibodies to bradykinin (NABB) and the indices of endothelial function.

We revealed alterations in the content of NABB in all groups of patients as compared with the control group. Their degree depended upon the disease and was highest in patients with stroke. Simultaneously we revealed impaired functioning of the vascular endothelium, the key manifestation of which was a pronounced decrease in the endothelium-dependent vasodilation in patients with stroke. Despite different directivity of alterations of certain indices of endothelial function in the groups of patients, we revealed statistically significant correlations of the alterations with the content of NABB.

KEY WORDS: ischaemic stroke, arterial hypertension, kinin regulation, endothelium.

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