Intraoperative hypoxic preconditioning as a method of neuroprotection in operations on internal carotid arteries

Gorokhov A.S., Shipulin V.M., Podoksenov Yu.K., Kozlov B.N., Kuznetsov M.S., Shishneva E.V., Panfilov D.S., Plotnikov M.P., Lebedeva E.V.

Department of Cardiovascular Surgery Research Institute of Cardiology under the Siberian Branch of the Russian Academy of Medical Sciences, Tomsk, Russia

The present work was aimed at assessing safety and efficacy of hypoxic preconditioning of the brain as a method of protecting the central nervous system during operations on the internal carotid artery in patients presenting with atherosclerotic lesions of the carotid arteries. The study included a total of 72 patients who underwent carotid endarterectomy for haemodynamically significant atherosclerosis of carotid arteries. Based on the obtained findings, a conclusion was made on a possibility of using intraoperative hypoxic preconditioning for prevention of ischaemic complications from the development in the perioperative period.

KEY WORDS: internal carotid artery, hypoxic preconditioning, carotid endarterectomy, stenosing atherosclerosis.

P. 105

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