PREDICTION OF REMOTE RESULTS AFTER SURGICAL MANAGEMENT OF PATIENTS PRESENTING WITH ATHEROSCLEROSIS OBLITERANS OF THE LOWERLIMB ARTERIES

Kuznetsov M.R.¹, Boldin B.V.¹, Koshkin V.M.³, Rodionov S.V.¹, Tourkin P.Yu.¹, Khaitov M.R.³, Vorontsov V.M.⁴, Pineguin B.V.³
¹ Chair of Faculty Surgery of the Moscow Department of the Russian State Medical University,
² Chair of Faculty Surgery of the Therapeutic Department of the Russian State Medical University,
³ Institute of Immunology of Federal Medicobiological Agency,
⁴ Centre of the Russian Academy of Sciences named after A. A. Doroditsyn,
Moscow, Russia

Forecasting the development of implants' narrowing appears to be one of the most important problems encountered in vascular surgery today. The present study was therefore undertaken to work out a comprehensive diagnostic methodology making it possible to reliably predict the development of stenosis of vascular anastomoses during the postoperative period in patients presenting with atherosclerosis obliterans.

The work was based upon the findings obtained by examining a total of seventynine patients diagnosed with atherosclerosis obliterans of the lowerlimbs arteries, also including assessment of a large number of haemodynamic and immunological parameters both before and after reconstructive vascular interventions.

The study showed substantial dynamics of a series of immunological and haemodynamic indices on the background of the operation and during the postoperative period. Based on the mathematical processing of the obtained data, the authors managed to reveal the factors playing a leading role in the development of stenosis, having also worked out a prognostic algorithm making it possible with high reliability to predict the development of stenosis of arterial anastomoses.

KEY WORDS: prediction, remote results of surgical management, pathogenetic therapy, atherosclerosis, endothelium, reconstructive operations, shunting, cytokines, ischaemia.

P. 112

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