THE ROLE OF MATRIX METAL PROTEINASES IN THE DEVELOPMENT OF RESTENOSES AFTER TRANSCUTANEOUS CORONARY INTERVENTIONS

O.A. Zemlyanskaya
A.L. Myasnikov Institute of Clinical Cardiology, Russian Cardiology Scientific and Industrial Complex, RF Ministry of Public Health,
Moscow, Russia

Endovascular coronary interventions for CAD induce restenoses in 20-50% of patients after 3-6 months. Following angioplasty or stenting restenosis arises from constrictive remodeling of the arterial wall and intimal hyperplasia. The damaged arteries provoke migration and proliferation of smooth muscle cells as a result of which there forms the neointima with accumulation of the extracellular matrix in the arterial intimal layer. These processes are regulated by matrix metal proteinases (MMP) and their tissue inhibitors. The rise of the MMP level in the dilated coronary arteries leads to vascular remodeling and formation of restenosis due to the effect on vascular smooth cell migration and thrombosis.

KEY WORDS: matrix metal proteinases, restenosis, coronary angioplasty.

P. 29-35

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