SPECTRUM OF LIPID PLASMA CONCENTRATIONS TWO MONTHS AFTER CORONARY ARTERY BYPASS SURGERY

L.N. lljina, O.I. Aphanasjeva, M.V. Ezhov, G.F. Benevolenskaya, R.S. Akchurin, S.N. Pokrovsky
Department of Cardiovascular Surgery,
Russian Cardiologic Scientific and Industry Complex,
Moscow, Russia

Forty one patients with ischemic heart disease (men aged from 46 to 68, mean 55±6) were examined before and after aortocoronary bypass surgery. Plasma lipids, lipoproteins and apolipoproteins were measured preoperatively and in early postoperative period (1, 2, 3, 4, 6 and 8 weeks after procedure). Patients with secondary hyperlipidemias were excluded from the study. Preoperative parameters were as follows: lipoprotein (a) – 40±37 mg/dl, total cholesterol – 6.0±1.4 mm/I, triglycerides – 2.3±1.9 mmol/l, LDL cholesterol – 3.2±1.2 mmol/l, HDL cholesterol – 0.8±0.3 mmol/l, apoAl – 137±20 mg/dl, apoB – 161±50 mg/dl. Maximal reduction of lipids and apolipoproteins was observed I week after operation: total cholesterol – 22% (p<0.001), triglycerides – 11%, LDL cholesterol – 33% (p<0.001), HDL cholesterol – 25% (p<0.001), apoAl – 14% (p<0.001), apoB – 21% (p<0.001). Concentration of Lp(a) was maximal 2-4 weeks after operation (20%, p<0.01) and can be evaluated as indirect evidence of Lp(a) participation in surgical trauma reparation.

KEY WORDS: Aorto-coronary bypass, ischemic heart disease, plasma lipid spectrum.

P. 10

« Back